Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
نویسندگان
چکیده
منابع مشابه
Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration
The amyloid hypothesis of Alzheimer's disease (AD) pathogen-esis maintains that the key event is the production of specific C-terminal amyloid-β (Aβ) peptides following the abnormal proteolytic cleavage of the amyloid precursor protein (Vassar and Citron, 2000). Aβ peptides self-aggregate and are found in multiple forms from small soluble monomers and oligomers to much larger fibrils and plaque...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2018
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2017.12.007